5 Main Roles of Guggul Extract for Weight Loss

Ayurveda is India’s traditional medicine system and this rich source of literature makes a point of a herbal remedy for every disease. The foundation of today’s nutraceutical industry is Ayurveda together with Unani and Traditional Chinese Medicine. Guggul is a herb that can help weight loss issues with cholesterol, arthritis, atherosclerosis, etc.,

Guggul is mentioned 3,000 to 10,000 years ago in the Vedas, India’s holy scriptures for treating human diseases.In 1966, an Indian medical scientist introduced Guggul to the science globe for the treatment of atherosclerosis.It was approved to be sold as a drug in 1986 to reduce blood lipid concentrations. It was introduced to treat cholesterol and heart disease in Western Medical literature in the 1990s.

Guggul is a  short shrub found mainly in India, Bangladesh, and Pakistan. This extract’s active ingredient is guggulsterone. Guggul has antimicrobial, antioxidant and anti-inflammatory characteristics. It is used to cure dermatitis and increases the texture and complexion of the skin as well. It is mainly used to lower cholesterol concentrations.

Guggul for Weight Loss

guggul for weight loss

A study was conducted of Ayurvedic literature in which it was indicated that classic Ayurvedic literature states that Guggul is superior among other drugs used to cure (obesity). Old guggul is efficient in treating obesity, especially guggul that has been stored for a year.Let’s go over the guggul studies and its impact on obesity and metabolic disorders.

1- It inhibits the development of fat cells

Fat cell development is an complex method requiring the participation of a variety of biological molecules in cell signaling. One such biological molecule is the Farnesoid X receptor whose activation controls the growth of fat cells and the activity of insulin. Guggulsterone is an antagonist of the farnesoid X receptor, inhibiting the action of this biological target could justify its anti-obesity impact.

In a cell culture research, guggulsterones were used to treat mature and growing fat cells, while guggulsterones had the following effects:

 1- Inhibiting fat cell growth.

2- Destroying fat cells.

3- Promoting fat breakdown and preventing fat accumulation in mature fat cells.

Researchers found on the basis of these results that guggul has an anti-obesity effect.

Another research conducted by the same scientists showed that genistein (a plant-based estrogen) works synergistically along with guggulsterone, inhibiting fat cell growth and preventing fat accumulation. Similar findings have been proven for the xanthohumol (a natural compound found in beer hops) and guggulsterone that together enhances fat breakdown.

What does that mean? Cell culture studies have found that guggulsterone, alone or with other bioactive ingredients, inhibit the growth of fat cells and prevent fat accumulation.

2- It influences appetite

guggul for weight loss

Defense Food Research Laboratory, Mysore, India, reviewed the impact of guggulsterone on appetite-regulating hormones.  Higher doses of guggulsterone were provided to animals. A dose of 400mg / kg was noticed to decrease the food consumption and prevent an increase in body weight for 15 days. There has also been a decline in the concentrations of ghrelin-‘hunger hormone, glucose and blood lipid, and an increase in leptin-‘satiety hormone, serotonin, and dopamine.

What does that mean? An animal research demonstrates that by controlling gastric hormones and brain chemicals, guggulsterone can reduce hunger.

3- It influences thyroid functioning

guggul for weight loss

Researchers at the University of Banaras Hindu, India, discovered that guggulsterone can control thyroid activity.  Z-guggulsterone showed powerful thyroid-stimulating activity when administered to albino rats. There was an increase in thyroid iodine uptake and increased thyroid-related enzyme activity was observed. The thyroid is one of the most important organs involved in metabolism regulation. The thyroid’s poor functioning can influence body weight.

What does that mean? Animal research demonstrates that guggulsterone stimulates thyroid activity which can also affect body weight.

4- It is used to treat cholesterol

Kuppurajan et al found that blood lipids were considerably lowered by gum guggul given to hyperlipidemic non-obese individuals at 2 g per day for 21 days.  Another research that Kotiyal and his fellow scientists conducted in 1979 showed similar research within 4 weeks. A few human-related clinical studies indicate that supplementation with guggul has little or no effect on people with high cholesterol levels. A review of guggul-centered research and their impact on high cholesterol and blood lipids revealed misleading outcomes. Some studies have shown beneficial outcomes, while others have shown no impact. The side effects have also been observed.

What is this research going to do? Ayurveda and Indian research studies suggest that guggul is helpful in managing problems with cholesterol. Guggul’s impact on cholesterol is inconclusive as far as total scientific evidence is concerned.

5- It has a blood sugar lowering effect

guggul for weight loss

Diabetes is a widespread consequence of obesity. Furthermore, impaired glucose tolerance and insulin activity may result in increased appetite and subsequent weight gain. Guggul’s impact has been researched on high-fat diet diabetic animal model. Guggulsterone inverted all the unhealthy modifications that the high-fat diet brought about. It decreased glucose concentrations and increased sensitivity of insulin. Other animal studies also indicate that Commiphora Mukul ethanol gum resin extract has an antihyperglycemic impact which reduces the effect of blood sugar. Moreover, these studies found enhancement in the status of antioxidants and enhanced sensitivity of insulin. Researchers believe that guggul extract in diabetes or insulin resistance can be used as an adjuvant therapy.

What does that mean? Guggul extract can be used as an addition on treatment to high-fat diet induced obesity. 

Human Studies on Guggul for Weight Loss

A research on guggul and its impact on individuals was organized by Swami Prakashananda Ayurveda Research Centre, Mumbai, India. It recommended Low-calorie diet and brisk walk were. Besides that, some participants took guggul 1.5-3g / day for thirty days. In the group receiving guggul treatment, weight loss was higher (around 2.25 kg). All participants weighing more than 90 kg lost weight in the guggul group while there was no weight loss for 3 people in the non-drug group.

It was found that guggul can help in the treatment of obesity with a low-calorie diet. Kepar, a natural supplement made in Italy, includes numerous components of plants such as turmeric, guggul, chlorgenic acid (green coffee bean), etc. Kepar was provided in at 2 pills daily for 4 months with regular metabolic syndrome treatment. Significant decreases were observed in body weight, BMI, circumference of the waist and cholesterol concentrations. However, both studies found that to confirm these outcomes, it is necessary to conduct larger studies with longer follow-up periods.

What does that mean? Limited experiments indicate that guggul is a good reason for weight loss. To confirm these outcomes, larger and more concrete researches are required.

Perfect Dosage of Guggul for Weight Loss

Maryland University recommends a 75-100 mg daily dose divided into 3 doses for cholesterol treatment. In humans, dose up to 1000 and 2000 mg were also tested. But starting with small doses is good. Gum guggul can be taken at 1.5-3 g daily doses.


There are various guggul Ayurvedic treatments available and it is best to check with Ayurvedic physician for this. Few side effects observed with consumption of guggul include stomach  pain and allergic rash.  Guggul should be prevented for:

• Pregnancy

• Hormonal imbalance

• Acute infection of the kidney

• Use of thyroid supplements

• Use of cholesterol-lowering medications.

Guggul may have interactions with other drugs so prevent it if you take any other medicines.  Before getting guggul supplements, consult a healthcare specialist.

Disclaimer: We strive to provide data that is existing and relevant, but drugs / supplements generally have a different effect on each person. It is therefore best to consult a physician about the side effects, drug interactions, and the appropriate dosage.

The Last Word

Traditional medicine literature and preliminary research indicate that guggul has anti-obesity characteristics. But in terms of human studies, there is not enough proof to demonstrate that supplementation with guggul can trigger important weight loss. So it’s hard to say that guggul is going to assist you lose fat. At first, you can try small doses of guggul and observe any changes for your body within a month if you don’t experience any side effect. It is recommended to receive advice on this from an Ayurvedic practitioner. Share your experiences with us if you’ve tried guggul.

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For more information about Guggul, you can see: https://www.webmd.com/vitamins/ai/ingredientmono-591/guggul

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